Mahidol University introduces CAR-T cell remedy for B-cell leukaemia in Thailand

Mahidol University has launched Chimeric Antigen Receptor (CAR) modified T-cell remedy for the treatment of B-cell leukaemia, making Thailand the first nation in the ASEAN region to adopt this advanced medical method.
Banjong Mahaisawariya, President of Mahidol University, noted that the university’s ability to implement a remedy presently used for certain blood cancers came because of a strategic coverage to advertise integration between numerous departments, reports Bangkok Post.
CAR remedy is taken into account one of the few remedy options for patients with B-cell leukaemia, which is commonly extra proof against chemotherapy when in comparability with other types of most cancers. Banjong expressed hope that the event of this therapy domestically would considerably cut back the financial burden of remedy, as importing it from abroad is kind of expensive.
“This success shall be key to the future of Thai medicine,” Banjong mentioned.
Piyamitr Sritara, dean of the Faculty of Medicine at Ramathibodi Hospital, revealed that the college collaborated with other institutes, state companies, and the non-public sector to trial CAR-T cell analysis and production in compliance with European Medicines Agency standards.
Fully refundable is now being reviewed by the Food and Drug Administration (FDA) in preparation for an utility for worldwide certification,” Sritara added.
The venture has garnered help from the Institute for Technology and Innovation Management, the National Science and Technology Development Agency, the Health Systems Research Institute, the Program Management Unit Competitiveness, the Office of National Higher Education Science Research and Innovation Policy Council, and Rama Foundation and Genepeutic Bio Co Ltd.
Suradej Hongeng, a paediatrics lecturer at Ramathibodi Hospital, explained that research on this remedy began in 2014, with the therapy first tested on ten B-cell leukaemia patients who displayed positive results.
Regarding the production course of, Hongeng said that researchers collect white blood cells from patients or their relations, then culture and genetically modify them in the laboratory for about two to a few weeks earlier than offering the remedy to patients.
In some cases, it was reported that abnormalities in white blood cells vanished from blood and bone marrow inside a two to four-week timeframe..

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